CovidV2, Main, Exploration, bibRecord, 001772

Profiling and Searching for RNA Pseudoknot Structures in Genomes

Identifieur interne : 001772 ( Main/Exploration ); précédent : 001771; suivant : 001773

Profiling and Searching for RNA Pseudoknot Structures in Genomes

Auteurs : Chunmei Liu [États-Unis] ; Yinglei Song [États-Unis] ; Russell L. Malmberg [États-Unis] ; Liming Cai [États-Unis]

Source :

Lecture Notes in Computer Science [ 0302-9743 ]

RBID : ISTEX:98B9F45764CD3700D5901EB6860AAAEE7C7BBD7D

Abstract

Abstract: We developed a new method that can profile and efficiently search for pseudoknot structures in noncoding RNA genes. It profiles interleaving stems in pseudoknot structures with independent Covariance Model (CM) components. The statistical alignment score for searching is obtained by combining the alignment scores from all CM components. Our experiments show that the model can achieve excellent accuracy on both random and biological data. The efficiency achieved by the method makes it possible to search for structures that contain pseudoknot in genomes of a variety of organisms.

Url:

DOI: 10.1007/11567752_2

Affiliations:

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Profiling and Searching for RNA Pseudoknot Structures in Genomes

Profiling and Searching for RNA Pseudoknot Structures in Genomes

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Abstract

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